Editor in Chief Dr KK Aggarwal, Padma Shri Awardee                                                                               Dated:04 January,2020

HIV patients lose smallpox immunity despite vaccine: Study

The study, published in the Journal of Infectious Diseases on HIV-associated immune amnesia could explain why people living with HIV still tend to have shorter lives on average than their HIV-negative counterparts despite being on antiretroviral therapy.

New York: HIV patients lose immunity to smallpox even though they were vaccinated against the disease as children and have had much of their immune system restored with anti-retroviral therapy, says a new study.

Antiretroviral therapy (ART) is the use of HIV medicines to treat HIV infection. It helps people with HIV live longer, healthier lives and reduces the risk of HIV transmission....read more


FDA Makes Legal Smoking raised to 21: All countries should raise it and make it uniform

The smoking age is the minimum legal age required to purchase or smoke tobacco products. Most countries have laws that restrict those below a minimum age from legally purchasing tobacco products.

The U.S. Food and Drug Administration has raised the legal smoking age from 18 to 21. As per FDA “On December 20, 2019, the President signed legislation to amend the Federal Food, Drug, and Cosmetic Act, and raise the federal minimum age of sale of tobacco products from 18 to 21 years. It is now illegal for a retailer to sell any tobacco product to anyone under 21.” ....read more


What is the importance of life force?

A physical body becomes useless once the life force is gone. The same body, which was lovable to everyone, becomes a liability after death. Everyone wants to dispose it as early as possible, as keeping a dead body at home is considered a bad omen.

During the transfer of dead body from one place to another, nobody wants to keep the body in a vehicle other than a hearse van, whose job is only to transport dead bodies. No family will be willing to carry the dead body of a person in a car in which the deceased person had been traveling or driving for years....read more


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Healthcare News Monitor

Illumina abandons $1.2 bln deal to buy rival Pacific Biosciences
ET Healthworld- Reuters

Illumina Inc on Thursday agreed to terminate the $1.2 billion deal to buy smaller rival Pacific Biosciences of California Inc, weeks after the U.S. competition watchdog filed a complaint to block the purchase. Gene sequencing company Illumina would pay Pacific Biosciences $98 million for the terminated deal, which was announced in 2018 and had attracted scrutiny from antitrust authorities in the United States and UK, both the companies said in a joint statement. Illumina is a major player in the nascent gene sequencing space, which involves analyzing the genome, and can among other uses, identify inherited disorders and markers of disease progression. In its complaint last month, the U.S. Federal Trade Commission raised concerns that Illumina wanted the deal in order to prevent Pacific Biosciences from developing into a competitor in the market for next-generation DNA sequencing.

Antabio receives US$ 4.4 mn funding from CARB-X to develop new treatment for Pseudomonas aeruginosa infections in CF patients
Pharmabiz

Antabio SAS, the biopharmaceutical company focused on developing a broad pipeline of antibacterial treatments against life threatening WHO critical priority pathogens, announces that it has been awarded up to US$ 4.4 million in a second tranche funding from CARB-X, the global non-profit partnership dedicated to tackling the global rising threat of drug-resistant bacteria. The funding is to support the development of Antabio's novel small molecule candidate for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis (CF) patients. This new tranche, part of a CARB-X award announced in July 2017, will be used to advance Antabio's Pseudomonas Elastase Inhibitor (PEi) programme up to completion of non-GLP preclinical studies. The additional funding recognizes Antabio's successful completion of project milestones during the first contractual period leading to the identification of a preclinical candidate. Antabio's innovative PEi programme seeks to develop an inhaled product to be used as an adjunct to existing therapy and which will aim to reduce the severity of P. aeruginosa disease and enhance pathogen clearance by targeting the LasB elastase, a key virulence determinant that contributes to tissue damage and inflammation in infected CF lungs. Antabio believes the PEi product, with its novel target and groundbreaking mechanism of action, has the potential to significantly enhance the effectiveness of existing treatments for CF patients. Cystic fibrosis (CF) is a genetic condition leading to long-term infections and progressive lung damage. The majority (>80%) of adult CF patients have acute and chronic infections caused by the bacterium P. aeruginosa, which has adapted to resist immune clearance and conventional antibiotics, leading to treatment failure, chronic infection and recurrent acute exacerbations. P. aeruginosa is one of the most critical pathogens urgently requiring alternative treatment strategies, according to the World Health Organization (WHO). Marc Lemonnier, Antabio's CEO, commented, "We are very pleased by CARB-X's continued financial support for our program focused on the development of our novel Pseudomonas elastase inhibitors. We believe that this program has the potential to deliver new molecules that will enhance the effects of the current antibiotics and improve the treatment of infections in CF patients. Antabio is committed to developing new truly innovative treatment options that can address the growing global issue of antimicrobial resistance and which can deliver potentially significant life-saving clinical benefits to patients."

Harsh Vardhan writes to Rajasthan CM over Kota hospital deaths, assures him of centre's support
ET Healthworld –ANI

With the death toll of infants in JK Lon Hospital in Rajasthan's Kota mounting to over 100 in nearly a month, Union Health Minister Harsh Vardhan said on Thursday that he has written to Rajasthan Chief Minister Ashok Gehlot, requesting him to look into the matter and assured him of "all kind of support" from the centre on the same. "I have written a letter to Rajasthan Chief Minister Ashok Gehlot requesting him to look into the matter. We have assured all kind of support from our side. The number of deaths is definitely hig.h0er this time compared to last few years," Vardhan said. He also urged for a joint effort by administration, doctors and others to evaluate the cause and ensure that there was no lack of facility at the hospital. "I believe that all people concerned, including the state government, hospital administration, doctors should get into the depth of the matter and if they need any sort of help, including the financial assistance, they should ask for it so that there is no lack of facility," he added. Three more children died in the JK Lon hospital in Rajasthan's Kota district on the first two days of the new year, taking the death toll to 103, an official said on Thursday. All three died during the treatment. While one was admitted here due to drastic weight loss, the other two were transferred from another hospital.

Absence of specialist docs plagues Indira Gandhi hospital
ET Healthworld- TNN

The Supreme Court Monitoring Committee, set up by the apex court to keep a watch on medical facilities being provided to survivors of the 1984 Bhopal Gas Disaster, while referring to its visit to Indira Gandhi Women and Children Hospital on Sultania Road, presented a report before the Madhya Pradesh high court on December 18, 2019. The monitoring committee said, “11 posts of medical officers and six posts of specialists, including that of radiologist, pathologist, medical and surgical specialists and blood bank officers were recommended to be filled up”. It was also recommended that posts as sanctioned should be filled up by regular channel. It was not only a large number of vacancies of medical officers and specialists that the monitoring committee took note of, but also the fact that beds and bed sheets were also not available for indoor patients in the hospital. The monitoring committee further recommended that the indoor patient department (IPD) be furnished by providing necessary cots/beds and the repair of damaged and useless cots/beds should be undertaken on an urgent basis. It also stated that lockers, benches and sufficient number of bed sheets be also provided.