Editor in Chief Dr KK Aggarwal, Padma Shri Awardee

Dated: 5 th April, 2019

Morning Medtalks With Dr KK

1. Myocardial infarction with non-obstructive coronary arteries (MINOCA): A new document, published in Circulation helps physicians better recognise patients with this condition. It is especially important for women, who represent a disproportionate number of MINOCA cases. Some patients who have chest pain and elevated heart enzymes, but do not have severe narrowing of their arteries are told that they did not have a heart attack, and this is often an incorrect diagnosis. As a result, doctors often send these patients home without protective medications and dont tell them about preventive measures.

2. Drinking a bottle of wine per week is equivalent to smoking five to 10 cigarettes a week when it comes to increasing the lifetime risk of developing cancer. For women, consumption of one bottle of wine per week increased the absolute lifetime risk of cancer to the same extent as smoking 10 cigarettes a week, largely driven by a heightened risk of breast cancer. Among men, drinking a bottle of wine per week boosted the absolute lifetime risk of cancer equivalent to smoking five cigarettes. The findings were published online March 28 in BMC Public Health.

3. The FDA expanded the indications of palbociclib (Ibrance) on Thursday to include breast cancer in men with advanced or metastatic hormone receptor-positive, HER2-negative disease.

4. Oral contraceptive use has been associated with a reduced overall risk of ovarian cancer, and new research presented at the American Association for Cancer Research meeting found that this protection extended to the most fatal forms of the disease.

5. Young, healthy obese individuals who consumed olive oil at least once a week had platelets that were less likely to clot when exposed to platelet-activation agonists. Ruina Zhang, a medical student at NYU School of Medicine, New York City, presented these findings in a poster at the American Heart Association (AHA)

6. Eating too much processed food can increase inflammation, which impairs the production of ATP and energy. Or, if you're older and your appetite isn't what it used to be, you may not give your body the calories and fuel it needs to function. On the flip side, if you're eating too much food at one time, that can cause blood sugar spikes and lead to fatigue.The fatty acids in protein-rich foods also help boost ATP. And aim for smaller meals with snacks in between to provide your body with a steady supply of nutrients and fewer blood sugar spikes.

7. A lack of sleep increases cortisol and also promotes inflammation. If sleep issues are caused by sleep apnoea (pauses in breathing during sleep), the dips in blood oxygen levels lowers ATP and energy. Sleep hygiene: go to bed and wake up at the same time each day, and keep your room cool, quiet, and free of electronics, which stimulate your brain.

8. Evidence suggests that people with mild cognitive impairment who do aerobic exercise three times per week and follow the DASH diet experience an improvement in executive function

9. About 10% of people report muscle aches when taking statins. In some cases, other health conditions such as arthritis, obesity, or just aging may be to blame. Doing exercise or yard work can cause muscle aches

10.People who sleep less than six hours per night or who have poor quality sleep may be more likely to develop early atherosclerosis in the arteries of the neck and upper leg.

Where can prostate cancer spread?

In theory, prostate cancer cells can spread anywhere in the body. In practice, though, most cases of prostate cancer metastasis occur in the lymph nodes and the bones.

More commonly prostate cancer metastasis can occur in the:

  • Bones
  • Lymph nodes
  • Lungs
  • Liver
  • Brain
  • Rare locations of prostate cancer metastasis include:

  • Adrenal glands
  • Breasts
  • Eyes
  • Kidneys
  • Muscles
  • Pancreas
  • Salivary glands
  • Spleen

  • Can pomegranate juice slow the growth of prostate cancer?

    Mayo Clinic Excerpts: Some research suggests that drinking pomegranate juice may slow the progression of prostate cancer.

    1. In a study of men with recurrent prostate cancer and rising prostate-specific antigen (PSA) levels, researchers found that taking pomegranate juice extract significantly slowed the rate at which PSA was rising (PSA doubling time). A longer PSA doubling time can indicate that the cancer may be progressing less rapidly. But this study did not use a control or placebo group. Nor did it measure overall survival.

    2. Another study found that the length of time it took for PSA to double after surgery or radiation for prostate cancer was significantly longer in men who drank 8 ounces (237 milliliters) of pomegranate juice daily for up to two years. Other studies have found that certain compounds in pomegranate juice inhibited the growth of prostate cancer cells in the laboratory.

    Although pomegranate juice is generally safe, there is evidence that it may affect how your body processes certain prescription medications. Those medications include the blood thinner warfarin and some drugs used to treat high blood pressure and high cholesterol.

    Dated: 4th April, 2019

    Current Temperature Status and Warning for next five days

    Heat Wave and Temperature Observed Yesterday (Past 24 hours from 0830 hrs IST of 03 April to 0830 hrs IST 04 April, 2019)

    Heat Wave:

    Yesterday, heat wave conditions were observed at some parts over Rajasthan; at isolated pockets over Gujarat state,Madhya Maharashtra and Chhattisgarh. (Annexure 1 & 2).

    Maximum Temperature

    Maximum temperatures were markedly above normal (5.1C or more) at most places over Jammu & Kashmir and West Rajasthan; at a few places over Himachal Pradesh and East Rajasthan; at isolated places over Saurashtra & Kutch; appreciably above normal (3.1C to 5.0C) at many places over West Madhya Pradesh and Marathwada; at a few places over West Uttar Pradesh, East Madhya Pradesh, Vidarbha, Gujarat region, Madhya Maharashtra and Chhattisgarh; at isolated places over Punjab, Haryana, Chandigarh & Delhi, East Uttar Pradesh, Konkan & Goa, Karnataka and Rayalaseema; above normal (1.6C to 3.0C) at most places over Jharkhand; at many places over Uttarakhand and Kerala; at a few places over Odisha and Tamil Nadu & Puducherry; at isolated places over Gangetic West Bengal. Yesterday, the highest maximum temperature of 43.3C was recorded at Rajkot (Saurashtra & Kutch) over the country. (Annexure 1 & 2).

    Temperatures Recorded at 1430 Hours IST of Today, the 04 th April, 2019

  • Akola (Vidarbha) recorded a maximum temperature of 43.4C (Annexure 3).
  • Temperatures recorded at 1430 hours IST of today have risen by 1-3C at most places over Rajasthan, Punjab, Haryana, Delhi, Gujarat region and East Madhya Pradesh; at many places over Jharkhand and Tamilnadu & Puducherry; at a few places over Uttar Pradesh, Bihar and Jammu & Kashmir; at one or two pockets over Himachal Pradesh, Uttarakhand, West Madhya Pradesh, Saurashtra & Kutch, Madhya Maharashtra, Kerala, Coastal Andhra Pradesh, Odisha, Chhattisgarh and northeastern states (Annexure 4).

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