Editor in Chief Dr KK Aggarwal, Padma Shri Awardee

Dated: 12th May, 2019

NIH trial evaluates long-acting HIV medication in patients unable to adhere to strict daily regimens

A clinical trial to evaluate long-acting antiretroviral therapy (ART) for maintaining HIV suppression in people for whom adhering to conventional daily oral ART has been a challenge has begun at research sites across the United States. The study, called Long-Acting Therapy to Improve Treatment Success in Daily Life, or LATITUDE, will help determine whether a combination of two experimental injectable formulations of ART are superior to conventional oral ART in managing HIV infection in this population.

LATITUDE (also known as ACTG 5359) will test two experimental, long-acting injections of the antiretroviral drugs rilpivirine (RPV) and cabotegravir (CAB), which will be administered every 4 weeks by a health care professional in a research clinic. Throughout the study, investigators will evaluate volunteers’ viral load—the measure of virus in the blood—and other indicators of immune health to compare the treatment’s effectiveness to that of conventional oral ART… (NIH, May 9, 2019).

Fewer doctors in the US are self-employed now, finds AMA survey

Analysis of data from the American Medical Association’s (AMA’s) Physician Practice Benchmark Surveys by the American Medical Association (AMA) has found that for the first time, more physicians were employed than self-employed.

Between 2012 and 2018 the percentage of physicians in practices with 10 or fewer physicians dropped from 61.4 percent to 56.5 percent with much of that change driven by a shift away from solo practice

In addition to changes in practice size, practice ownership is shifting away from physician-owned practice (“private practice”) and toward working directly for a hospital or for a hospital-owned practice. In 2018, 47.4% of doctors involved in patient care were employed, while 45.9% were self-employed.

The AMA's latest Benchmark Survey, which has been conducted every 2 years since 2012, includes physicians who provide at least 20 hours of patient care per week, are not employed by the federal government, and practice in one of the 50 states or the District of Columbia. About 3500 physicians participated in the survey… (Medscape – AMA).

More than low income, homelessness has a greater impact on newborns

Infants born during a period of unstable housing resulting in homelessness had higher rates of low birth weight, respiratory problems, fever, allergies, injuries and developmental disorders; longer neonatal intensive care unit stays; more emergency department visits; and higher annual spending.

"Children born during a period of family homelessness have significantly greater health risks from birth through early childhood. Our analyses suggest that unstable housing's impact on infants and children goes beyond the more general effects of poverty," the authors write in the May 2019 issue of Health Affairs.

Current Temperature Status and Warning for next 24 hours

Heat Wave and Temperature Observed Yesterday (Past 24 hours from 0830 hrs IST of 11 May to 0830 hrs IST of 12 May, 2019)

Heat Wave:

Yesterday, Heat wave conditions were observed at isolated pockets over East Uttar Pradesh, Vidarbha, Bihar, Odisha, Telangana and Gangetic West Bengal. (Annexure 1 & 2).

Maximum Temperature

Maximum Temperature more than 40.0°C were recorded at most places over East Uttar Pradesh, Jharkhand, Vidarbha and Telangana; at many places over Marathwada & North Interior Karnataka,; at a few places over West Uttar Pradesh, Bihar, Madhya Pradesh, & Rayalseema and at isolated places over Haryana, Chandigarh & Delhi, Chhattisgarh, Odisha, Gangetic West Bengal, Coastal Andhra Pradesh, Madhya Maharashtra, Gujarat state and Tamilnadu & Puducherry.

Maximum temperature departures as on 11-05-2019: Maximum temperatures were appreciably above normal (3.1°C to 5.0°C) at most places over Bihar, Rayalaseema and Nagaland, Manipur, Mizoram & Tripura; at many places over Jharkhand; at a few places over Gangetic West Bengal and Odisha; at isolated places over Sub-Himalayan West Bengal & Sikkim, Telangana, Kerala and Tamilnadu & Puducherry; above normal (1.6°C to 3.0°C) at most places over South Interior Karnataka; at many places over Uttarakhand and North Interior Karnataka; at a few places over East Uttar Pradesh, Vidarbha, Madhya Maharashtra and Andaman & Nicobar Islands and at isolated places over West Uttar Pradesh and Coastal Karnataka. They were markedly below normal (-5.1°C or less) at isolated places over Himachal Pradesh; appreciably below normal (-3.1°C to -5.0°C) at a few places over Jammu & Kashmir, Assam & Meghalaya and Arunachal Pradesh; below normal (-1.6°C to -3.0°C) at many places over West Rajasthan; at a few places over Madhya Pradesh; at isolated places over East Rajasthan and Gujarat state and near normal over rest of the country.

The highest maximum temperature of 45.6°C was recorded at Khammam (Telangana).

Heat Wave Warnings for Next 24 hours (From 0830 hrs IST of 12 May to 0830 hrs IST of 13 May 2019):-


Understanding negotiation: First No than Yes

SFO: DIFT and FTID are two important negotiation principles.

Door-in-the-face (DITF) technique is a compliance method commonly studied in social psychology.

The persuader attempts to convince the respondent to comply by making a large unrealistic unreasonable request that the respondent will most likely turn down, much like a metaphorical slamming of a door in the persuader's face.

The respondent is then more likely to agree to a second, more reasonable request, than if that same request is made in isolation.....read more

Grave medical negligence: Three patients on ventilator die at this city hospital

Three patients on ventilator support died on Tuesday night at Tamil Nadu’s Madurai Government Hospital due to an unexpected power failure. After the incident, the kin of the deceased patients sat on a dharna in front of the hospital seeking action against the apathy of the concerned officials.

According to the relatives of the deceased, three people died & two more who were on ventilator were fighting for life after a power cut that continued for nearly two & half hours in Madurai.

The power cut happened after rains accompanied by thunderstorms lashed the temple town yesterday night......read more


Sawan Ka Mahina Pawan Kare Sor