Editor in Chief Dr KK Aggarwal, Padma Shri Awardee

Dated: 26th May, 2019

Do Not Use of Unauthorized Diabetes Devices

Now the US FDA has issued a warning against the use of unauthorized diabetes devices, insulin pumps and continuous glucose monitors as well as other nonapproved devices and algorithms used to create systems for automated insulin delivery.

As per the FDA statement "These unauthorized diabetes management devices have not been reviewed by the FDA to ensure they provide a reasonable assurance of safety and effectiveness for their intended use. Use of unauthorized devices could result in inaccurate glucose level readings or unsafe insulin dosing, which can lead to injury requiring medical intervention or death,"

The warning followed a case report of a patient using a system comprising an unauthorized insulin dosing device that receives electronic signals from an FDA-authorized glucose sensor and converts it to a glucose value using an unauthorized algorithm. The system gave the patient too much insulin in response to repeated incorrect high glucose values.

These devices were not designed to be used together and were combined in a way that had not been thoroughly tested for compatibility.

Off late we have been seeing cases of even FDA approved device failures like Johnson and Johnson hip implant and Medtronics pacemaker security alert. In these cases, it is easy to track, compensate and correct. But in unauthorised devices it can be risky.

Daily Aspirin May Lower Risk for Fatty Liver Progression

While evidence no longer supports the use of daily aspirin for primary prevention of cardiovascular disease a new study suggests that taking aspirin daily may prevent progression of nonalcoholic fatty liver disease (NAFLD) to liver fibrosis and nonalcoholic steatopepatitis (NASH). The study is published in May 8 in Clinical Gastroenterology and Hepatology.

Earlier the results from rodent studies also have suggested that aspirin may prevent progression to fibrosis in NAFLD.

Currently, > 30% of Indians have NAFLD, which is caused by fat accumulation in the organ. Up to 25% of individuals with NAFLD progress to liver fibrosis and are at risk for cirrhosis, liver cancer, and death.

The prospective study included 361 adults with biopsy-confirmed NAFLD who were enrolled in the Massachusetts General Hospital NAFLD Repository between 2006 and 2015. Among participants, 151 were already taking daily aspirin at the start of the study, mostly (54%) for primary cardiovascular disease prevention. Median duration of aspirin use at enrolment was 2.5 years.

Researchers confirmed NAFLD diagnoses through blinded medical record review. A blinded pathologist also assessed baseline liver biopsies.

Current Temperature Status and Warning for next 24 hours

Heat Wave and Temperature Observed Yesterday (Past 24 hours from 0830 hrs IST of 25 May to 0830 hrs IST of 26 May, 2019)

Heat Wave:

Yesterday, Heat Wave Conditions were observed in some part of Vidarbha and in isolated pockets over south Madhya Maharashtra. (Annexure 1 & 2).


Maximum Temperature more than 40.0C were recorded at most places over Madhya Pradesh, Vidarbha, Marathwada, Telangana; at many places over East Uttar Pradesh, Chhattisgarh, Gujarat Region, Rayalaseema; at a few places over Rajasthan, Saurashtra & Kutch, Madhya Maharashtra, Jharkhand, Odisha, Coastal Andhra Pradesh, North Interior Karnataka and at isolated places over West Uttar Pradesh, Bihar and Tamilnadu & Puducherry.

Maximum temperature departures as on 25-05-2019: Maximum temperatures were appreciably above normal (3.1C to 5.0C) at a few places over Vidarbha, Madhya Maharashtra and Odisha; at isolated places over Marathwada, Coastal Karnataka, Rayalseema and Tamilnadu & Puducherry; above normal (1.6C to 3.0C) at most places over North Interior Karnataka; at many places over East Madhya Pradesh, Konkan & Goa and Kerala; at a few places over Saurashtra & Kutch, Coastal Andhra Pradesh, Lakshadweep, Kerala, South Interior Karnataka and Telangana and at isolated places over Andaman & Nicobar Islands, Jharkhand, Konkan & Goa. They were appreciably below normal (-3.1C to -5.0C) at most places over Sub-Himalayan West Bengal & Sikkim; at a few places over Assam & Meghalaya; at isolated places over Punjab, Haryana, Chandigarh & Delhi, Himachal Pradesh and Nagaland, Manipur, Mizoram & Tripura; below normal (-1.6C to -3.0C) at a few places over Gangetic West Bengal and Jammu & Kashmir and at isolated places over West Uttar Pradesh and near normal over rest of the country.

Yesterday, the highest maximum temperature of 46.8C was recorded at Chandrapur (Vidarbha).

Heat Wave Warnings for Next 24 hours (From 0830 hrs IST of 26 May to 0830 hrs IST of 27 May 2019):-


eat Wave Conditions in some parts very likely over Vidarbha and in isolated pockets very likely over Telangana, south Madhya Maharashtra, Marathwada, East Madhya Pradesh, Chhattisgarh, Jharkhand and Odisha.

First diagnostic test to detect prosthetic joint infections

Prosthetic joint infections are a serious complication of joint replacement surgery, which necessitate surgical intervention. At present, potential infections are typically evaluated for with x-rays or laboratory analysis of joint fluid. This can be time consuming process.

But now the process may become simpler with the approval of a new diagnostic test to detect prosthetic joint infections.

The US Food and Drug Administration (FDA) has permitted marketing of the Synovasure Lateral Flow Test Kit as an aid for the detection of periprosthetic joint in the synovial fluid of patients being evaluated for revision surgery i.e. surgery performed to replace or compensate for a failed implant......read more

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